Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Parapapillary Atrophy in Stable and Progressive Open-angle Glaucoma

Budde W. M.1,2, Jonas J. B.1
1Dept. of Ophthalmology, Faculty for Clinical Medicine Mannheim of the Ruprecht-Karls University Heidelberg, Mannheim; 2Dept. of Ophthalmology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

Purpose: Occurrence and size of parapapillary atrophy PPA (zone beta) has been associated with glaucomatous optic atrophy. Aim of the study was to assess the incidence of enlargement of PPA in stable and progressive open-angle glaucoma.
Method: In a prospective glaucoma follow-up study 927 eyes (105 normal eyes, 302 eyes with ocular hypertension (OHT), 342 eyes with open-angle glaucoma (OAG) and 178 eyes with normal-tension glaucoma (NTG)) were included. Optic disc photographs taken annually were evaluated. Follow-up was 1.5 - 10 years. Two independent examiners judged optic disc slides of follow-up examinations for enlargement of PPA and for morphologic signs of glaucoma progression in comparison with baseline examination.
Results: In 16 eyes an enlargement of PPA could be observed after 4.1 ± 2.4 (0.5 - 9.1) years of follow-up. This occurred in no normal eye, in 1/302 (0.3%) OHT eye, in 12/342 (3.5%) OAG eyes, and in 3/178 (1.7%) NTG eyes. Enlargement of PPA developed in 5/106 (4.7%) progressive glaucoma eyes and in 10/414 (2.4%) stable glaucoma eyes.
Conclusions: PPA (zone beta) may enlarge during the course of open-angle glaucoma. This happens more frequent in progressive than in stable glaucoma. Even in progres


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