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Abstract
Abstract
VEGF in exudative ARMD
Lappas A.
Augenklinik der RWTH Aachen
Vascular endothelial growth factor (VEGF) is a specific proliferation factor for vascular endothelial cells and the most potent permeability factor. Age related macular degeneration (ARMD) is characterized by choroidal neovascularisations (CNV) and by impairment of the outer blood retinal barrier. Expression of VEGF could be demonstrated in surgically removed CNV. In vitro RPE have been shown to synthesize VEGF. When RPE cells were cocultivated with vascular endothelial cells they developed lower barrier properties. This effect was dependent on VEGF.
Obviously, VEGF could be an important part of the pathogenesis of ARMD. Further studies will show whether therapeutic inhibition of VEGF can influence the progression of the disease.