|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Animal models of neovascular AMD
Fauser S., Krohne T., Kociok N., Kirchhof B., Joussen A. M.
The lack of adequate animal models is a major problem in investigating choroidal neovascularisation (CNV) in age-related macular degeneration (AMD). Nevertheless, several models represent certain aspects of the disease. Here, we review available models of AMD. In the best established model, CNV is induced by laser-induced rupture of Bruch's membrane. However, the CNV is accompanied by an unspecific, local inflammation. Another popular model is the RCS rat where shed outer segments of the photoreceptor cells accumulate in the subretinal space due to a mutation in the Mertk gene. Therefore, it is predominantly a model for retinitis pigmentosa.