|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
CEACAM1 in Endothelial Cell Differentiation and Angiogenesis an In-vivo Model for Retinopathy
Horst A. K.1, Zubaty V.2, Valtink M.3, Wörpel V.2, Beauchemin N.4, Engelmann K.3, Wagener C.1
CEACAM1 (CEA-related cell adhesion molecule 1) is a ubiquitously expressed cellular adhesion molecule (epithelia, endothelia and leukocytes) of the CEA-family of immunoglobulins, that participates in early angiogenic events. Furthermore, CEACAM1 expression is dysregulated in a variety of human tumours. The angiogenic properties of CEACAM1 seem to be based in part on the signal transduction potential through its cytoplasmic domain. Founded on this information, transgenic mice (Tie2-CEACAM1-transgenic mice) were generated that overexpress CEACAM1 under the endothelial cell-specific control of the Tie2 receptor tyrosine kinase. The receptor tyrosine kinases Tie1 and Tie2 and their ligands, the angiopoietins, are central players in the regulation of angiogenesis. Overexpression of CEACAM1 in the endothelia of transgenic mice was verified by flow cytometric analysis. So far, no major defects in the vasculature of Tie2-CEACAM1-transgenic mice could be detected.