Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Crystalline Macular Deposits with Long-time Sea Buckthorn Juice Intake

Labus M., Ernst S., Weber U.
Dept. of Ophthalmology, Municipal Hospital, Braunschweig

Purpose: Macular crystalline deposits were described first in 1982 after therapy of light-induced skin diseases with a skin tanning agent containing the carotenoid canthaxanthin1. We found such crystals in a 73-year old patient after an approximately 20 years ìntake of sea buckthorn juice. The maximal cumulative dosage of carotenoids was estimated at 48 g.
Method: Clinical examination, fundus photography and angiography, visual field examination (Humphrey perimeter) with a 100 threshold test. Electrophysiology with standard- and multifocal (mf) ERG, VEP and EOG (Retiport, Roland Consult).
Results: Visual acuity c.c. (R/L) 0.7 / 1.0. Visual fields: Mean defect -3,31 / -3,61 db (p < 2%). ERG: Photopic plots were within normal limits. Scotopic: Prolonged b-wave latency at -25 db flash. MF ERG: Inconsistent results at repeated examinations. VEP: prolonged P 100 latencies (pattern rev., 10 25´ full field, Ctr. 97% 0,9 Hz). EOG: Arden quotient 2.810/2,002.
Conclusions: The results are compatible with a carotenoid-retinopathy that also can be accompanied by disturbances of the color sense and the dark adaptation. As nutritional (self-) therapy of age-related macular degeneration increases, the possibility of dose-related side-effects caused by carotenoid-containing food additives should be taken into account.
1Cortin P, Corriveau LA, Rousseau AP, Tardif Y, Malenfa


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