|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Successful Treatment of Conjunctivitis Lignosa: A Case Report
Spelsberg H.1, Eisert S.2, Reinhard T.3, Göbel U.2, Sundmacher R.1
Purpose: Pathogenetically, conjunctivitis lignosa is associated with an autosomal recessive inherited severe type-1-plasminogene deficiency. Decreased fibrinolytic activity of the tear fluid seems to be responsible for the development of thick membranes adhering to the tarsal conjunctiva. Fast recurrences were observed after surgical treatment alone. Among different topical therapeutic strategies, only the combination of steroids and heparine after surgical excision may lead to a recurrence-free interval. Recently, first promising success was reported with topical plasminogene.