Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Successful Treatment of Conjunctivitis Lignosa: A Case Report

Spelsberg H.1, Eisert S.2, Reinhard T.3, Göbel U.2, Sundmacher R.1
1Dept. of Ophthalmology, 2Paediatric Haematology and Oncology, Heinrich-Heine University, Dusseldorf
3Eye Hospital, Albert-Ludwigs-University, Freiburg

Purpose: Pathogenetically, conjunctivitis lignosa is associated with an autosomal recessive inherited severe type-1-plasminogene deficiency. Decreased fibrinolytic activity of the tear fluid seems to be responsible for the development of thick membranes adhering to the tarsal conjunctiva. Fast recurrences were observed after surgical treatment alone. Among different topical therapeutic strategies, only the combination of steroids and heparine after surgical excision may lead to a recurrence-free interval. Recently, first promising success was reported with topical plasminogene.
Method: Case report: In April 2002 three children with different stages of conjunctivitis lignosa of a big Turkish family were referred to our hospital. Severe plasminogen deficiency was proven in all children with a remaining plasminogen activity of 2-4%, which was not associated with the stage of the disease. A therapy was started in 2 children (1 girl, 1 boy). For fourteen days only the boy was treated with plasminogene drops (Eminase®) one per hour. The girl with more severe lesions showed an allergic reaction to these drops and was treated alternatively with heparine drops one per hour. No changes were observed. Surgical re


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