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Abstract
Abstract
Topical Anesthesia with Tetracaine 1%: Drops vs. Gel
Zink T., Babl J., Kampik A., Schönfeld C.-L.
Department of Ophthalmology, Ludwig-Maximilians University, Munich
Purpose: Tetracaine (1%) drops were compared with Tetracaine gel used in topical anesthesia for extracapsular surgery (ECCE). It was investigated, whether the application of the gel resulted in better analgesia without higher toxicity for the corneal endothelium.
Method: In this prospective randomized double blind clinical trial 59 patients underwent ECCE. 36 eyes underwent surgery under topical anesthesia receiving tetracaine drops (D), 23 eyes receiving tetracaine-gel (G). Phacoemulsification was performed in 28 eyes of the gel-group (GP) and in 23 eyes of the drop-group (DP). Hydrofragmentation and hydroexpression was performed in 8 eyes under topical anesthesia with Tetracaine-drops (DH). Incision techniques were Clear Cornea Incision for the phacoemulsification-technique and conjunctival incision, sclerocorneal tunnel and final adaption of the conjunctiva by electrocauterisation for the hydrofragmentation /hydroexpression-technique. In the phacoemulsification-groups Tetracaine of either galenic form was attributed double-blind. Parameters of examination were: best corrected visual acuity, slit-lamp examination, corneal endothelial cell count, time of phacoemulsification, duration of surgery, subjective pain score assessed with the visual analog scale (VAS), surgeon's satisfaction with topical anesthesia. Patients were followed up for 6 weeks.
Results: Topical anesthesia with Tetracainegel pro