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Abstract
Abstract
Expression of TGF-ß1 and TGF-ß2 in Failed Filtering Blebs of Patients with Pseudoexfoliation and Primary Open-angle Glaucoma
Kottler U. B.1,2, Schlötzer-Schrehardt U.1, Pfeiffer N.2, Naumann G. O. H.1, Jünemann A. G. M.1
1Department of Ophthalmology, University Erlangen-Nuremberg, Erlangen, 2University of Mainz
Purpose: Transforming growth factor (TGF) -ß1 and -ß2 are potent stimulators of proliferation, migration and matrix production of human Tenons capsule fibroblasts in vitro suggesting a significant influence on the conjunctival scarring response after glaucoma filtration surgery. In addition to significantly increased aqueous humor levels of TGF-ß1 in pseudoexfoliation (PEX)-syndrome/glaucoma and TGF-ß2 in primary open-angle glaucoma (POAG), local production of both isoforms by resident cells at the filtering site may adversely affect the outcome of glaucoma filtration surgery. We therefore investigated the expression of TGF-ß1 and -ß2 together with their binding protein LTBP-1 in failed filtering blebs in comparison with normal conjunctival specimens.
Method: Failed filtering blebs from 8 patients with POAG, 3 with PEX glaucoma and 4 with juvenile glaucoma, who had undergone revision surgery, and normal conjunctival biopsies with Tenons capsule were processed for light microscopic immunohistochemistry using antibodies against TGF-ß1, TGF-ß2 and LTBP-1.
Results: In normal conjunctival specimens, only TGF-ß2 was present in the conjunctival and subconjunctival stromal fibro