|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Trophic Capacity of Platelet Lysate on Corneal Epithelial Cells An Alternative to Autologous Serum Eye Drops for Ocular Surface Disease?
Geerling G., Harloff S., Liu L., Wedel T., Hartwig D.
Purpose: Eye drops prepared from serum have been successfully used to treat ocular surface disorders such as dry eyes or persistent epithelial defects. Their beneficial effect was attributed to a variety of growth factors present in serum. Platelets are a major source of growth factors in serum. They are available at adjustable concentrations in platelet rich suspensions from blood banks and following stimulation with thrombin release their growth factor content. We examined the epitheliotrophic capactiy of platelet lysates in comparison with serum in an in-vitro model of human corneal epithelial cells.