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Abstract
Abstract
Examination about the Incidence of Conjunctival Carcinoma in Atopic Keratoconjunctivitis
Engelhardt S.1, Reinhard T.2, Schilgen G.1, Kallen C. J.1, Böcking A.3, Sundmacher R.1
1Eye Hospital, 3Institute of Cytopathology, Heinrich-Heine University, Dusseldorf
2Eye Hospital, Albert-Ludwigs-University, Freiburg
Purpose: The incidence of conjunctival carcinoma is about 1.2 diseases per annum per million persons in Germany. In nearly half of the patients with atopic dermatitis chronical inflammation of eye-lids, conjunctiva and cornea is described. Because chronical inflammation is a predisposition for the development of cell dysplasia and malignoma, a correlation of neoplastic developments with atopic keratoconjunctivits is suspected. Since October 2000 all patients with atopic keratoconjunctivitis who consulted our clinic were examined cytologically and cytometrically. In 8 cases conjunctival carcinoma was diagnosed.
Method: 47 patients with chronic eye inflammation and atopia have been examined so far. The average age was 43.7 years (15-76 years) - 31 male and 16 female. The primary examination was done by cytological and cytometrical methods. The differentiation into carcinoma in situ and invasive carcinoma was done by biopsy.
Results: One patient with a maligne diagnosis in the cytological/cytrometrical examination refused the necessary bioptic differentiation. Histopathological differentiation in 7 out of 8 patients reveiled carcinoma in situ in