Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Effects of Dehydration on Corneal Tissue

Aurich H.1, Wirbelauer C.1, Jaroszewski J.2, Hartmann C.2, Pham D. T.1
1Department of Ophthalmology, Vivantes Klinikum Neukölln, Berlin; 2Charité, Department of Ophthalmology, Campus Virchow Klinikum, Humboldt University Berlin

Purpose: Optical online pachymetry (OP) allows central corneal thickness measurements over time. In this study, the effects of dehydration on corneal tissue was investigated.
Method: 6 Patients were examined with optical online pachymetry (4Optics AG) at a wavelength of 1310 nm and a frequency of 74 Hz before planned keratectomy with the excimer laser. Central corneal thickness was registered over 5 minutes after insertion of an eyelid speculum. Additionally, the influence of dehydration on non-transplantable human corneal grafts was examined.
Results: All measurements performed with OP were easy to perform and reproducible. The patients had an initial mean corneal thickness of 549.7 ± 26.9 µm. After 5 minutes, the central corneal thickness was reduced to 502.9 ± 24.4 µm (p<0,05). This corresponds to a mean corneal thinning of 46.8 µm (8.5%). Corneal grafts showed variable trends concerning central thickness, which can be attributed to changes in corneal tissue in the culture medium.
Conclusions: Optical online pachymetry revealed to be suitable for measurements of changes in central corneal thickness over time. Corneal dehydration effects should be considered, especially during refractive surgery.


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