Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Analysis of Occult Choroidal Neovascularization Using Three-dimensional Imaging Methods

Ahlers C.1, Michels S.1, Beckendorf A.1, Birngruber R.2, Schmidt-Erfurth U.1
1University Clinical Centre S-H, Campus Lübeck; 2Medical Laser Centre Lübeck GmbH

Purpose: Okkult choroidal neovascularizations (oCNV) were identified and charakterized using three-dimensional imaging and tools such as topographic angiography (TAG), retinal thickness analyzer (RTA) and optical coherence tomography (OCT).
Method: 28 Eyes of 27 patients with CNV underlying the retinal pigment epithelium (RPE) were diagnosed by ophthalmoscopy and angiography and examined by TAG, RTA and OCT. Typical retinal and choroidal characteristics were identified.
Results: All types of oCNV appeared as exsudative macular lesions with RPE detachment (PED). The fibrovacular type of CNV was seen as ill-defined late leakage with more or less homogenous pattern by conventional angiography. Using TAG analysis, the neovascular component of the lesion was localized and delineated as a flat prominence, retinal changes were not documented. Using RTA, neither the CNV nor the secondary retinal changes were detected. OCT offered a detailed image of intra- and subretinal exudative changes, mostly cystic in nature, but failed to show the CNV component. Single scans eventually demonstrated duplicated RPE and choriocapillary structures. Serous PED imposed as highly prominent fluid pools. By RTA, a negative version was seen with absence of the cen


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