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Abstract
Abstract
Interferon as a Treatment for Uveitis Associated with Multiple Sclerosis
Becker M. D.1, Hudde T.2, Fiehn C.3, Storch-Hagenlocher B.4,
Wildemann B.4, Trieschmann M.5, Heiligenhaus A.5
1Dept. of Ophthalmology, 3Dept. of Internal Medicine, 4Dept. of Neurology, University of Heidelberg; 2University Eye Hospital, University of Essen; 5Dept. Of Ophthalmology at St. Franziskus Hospital, Münster
Purpose: Besides optic neuritis (ON), multiple sclerosis (MS) may also involve the eye in the form of a bilateral uveitis. Interferon has been shown to have beneficial effects in patients with MS and/or ON. As shown in the model of experimental autoimmune encephalitis and uveitis (EAE), the neurological and ophthalmological manifestations seem to share similar pathogenic mechanisms. Aim of this pilot study was to evaluate the efficacy of interferon for MS-associated uveitis.
Method: We included 9 patients (8 female, 1 male) with proven MS and associated uveitis from 3 uveitis centers. Median age was 49 years (range 34-57). 7 patients were treated with interferon-b and 2 with interferon-a. Visual acuity, cell count in the aqueous humor and vitreous, as well as posterior segment vasoproliferative changes and presence of cystoid macula edema (CME) were documented. All patients had bilateral and 4 had granulomatous uveitis. Seven had retinal vasculitis, 5 patients had vasoproliferative changes at