Color Doppler Imaging in Primary Open-angle Glaucoma and Normal subjects
Boehm A. G.1, Bowd C.2, Pillunat L. E.1, Weinreb R. N.2
1Department of Ophthalmology, University of Dresden; 2Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla/USA
Purpose: To assess whether there are differences between normal subjects and primary open angle glaucoma patients (POAG) with regards to their ocular hemodynamics measured by Color Doppler Imaging (CDI).
Method: One randomly selected eye of 20 patients with POAG (age: 66.2±7.4y) and of 20 normal subjects (age: 59.3±13.3y) was examined (age difference: p=0.052). The POAG patients had repeatable visual field loss by Humphrey visual field 24-2. CDI retrobulbar blood velocities were measured at the central retinal artery (CRA), and the temporal and nasal short posterior ciliary arteries (TSPCA, NSPCA). Perfusion parameters were peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI). Students t-test was used to evaluate the differences between the groups. In addition a univariate linear regression analysis correcting for age, systolic blood pressure, diastolic blood pressure, heart rate and IOP measured by applanation tonometry was conducted. The Sidak correction was used to correct alpha for multiple comparisons.
Results: At the CRA RI was .725±.085 in normals and .799±.067 in POAG (p=.004), PSV.132±.0379 and .106±.023 (p=.013), and EDV .038±.019 and .022±.011(p=.003), respectively.
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