Differences in Autofluorescence in Patients with Age-related Maculopathy Depending on Funduscopic Findings
Mößner A.1, Einbock W.1, Jahn C.1, Schnurrbusch U. E. K.1, Holz F. G.2, Wolf S.1 for the FAM-study group
1Klinik und Poliklinik für Augenheilkunde, Universität Leipzig; 2Augenklinik, Universität Heidelberg
Purpose: The study group "fundusautofluorescene in age-related maculophathy" (FAM-study) deals with the lipofuscin dependent fundusautofluorescence (AF) and its prognostic meaning in patients with age-related maculophathy (ARM) and age related macular degeneration (ARMD). In this study we examined patients with drusen in age-related maculophathy (ARM) for changes in AF.
Method: Patients with ARM were recruited for this study. Examinations included ETDRS visual acuity, funduscopy, fundus photography, and AF imaging (HRA, Heidelberg Engineering, Germany). On the basis of fundus photographs ARM patients were categorized into 3 groups (ARM 1-3): ARM 1 (drusen size < 125µm), ARM 2 (drusen size >125µm), ARM 3 (drusen in "high risk" eyes). Changes in AF were analysed in relation to ARM categories 1-3. Furthermore they were correlated with ETDRS visual acuity.
Results: 96 patients (62 women, 34 men; mean age: 70 ± 8 years) were included in the study. 17 patients were categorized into group ARM 1 as well as into ARM 2, 62 patients into group ARM 3. AF of group ARM 1 showed no abnormalities in 11 (65%) cases, 4 eyes showed minimal, 2 eyes moderate changes of AF. In group ARM
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