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Abstract
Abstract
Expression of the Endothelial Cells Proliferation Marker Endoglin in Choroidal Neovascularization Membranes
Canbek S.1, Grisanti S.1, Kaiserling E.2, Lafaut B.3,4, Gelisken F.1, Bartz-Schmidt K. U.1
1Center of Ophthalmology, Department of Vitreoretinal Surgery and 2Institute of Pathology, Eberhard-Karls University Tuebingen; 3University of Ghent, Ghent/B; 4AZ St. Jan, Bruges/B
Purpose: Endoglin (CD105) is a membrane protein involved in the TGF-ß receptor signalling pathway with predominant expression by proliferating endothelial cells. The aim of this study is to analyze the expression of CD105 in choroidal neovascularization membranes (CNVM) and to correlate it with the proliferative status of CNVMs.
Method: Thirty surgically excised CNVM secondary to age-related macular degeneration were investigated by light microscopic immunohistochemistry and confocal immunofluorescence microscopy using verified antibodies for the endothelial cell markers CD105, von Willebrand factor (vWF) and CD34 and the proliferation marker Ki-67.
Results: A selective expression of CD34 and vWF as well as CD105 was found in endothelial cells. CD105 expression was elevated in vascular endothelial cells within CNVM, but a moderate CD105 expression could also be visualized in quiescent CD34 and vWF positive ocular vasculature. Ki-67 positive cells were detected in CNVMs, but these were rarely endothelial cells.
Conclusions: Endoglin expression in endo