Comparison of Fluorescein Angiography and Optical Coherence Tomography in the Evaluation of Patients with Choroidal Neovascularization after Photodynamic Therapy
Eter N.1, Spaide R.2
1Department of Ophthalmology, Medical Center, University of Bonn; 2Vitreous Retina Macula Consultants of New York/USA
Purpose: To investigate retinal morphology by means of fluorescein angiography (FA) and optical coherence tomography (OCT) in patients who have undergone photodynamic therapy (PDT) with Verteporfin.
Method: Sixty patients with predominantly classic choroidal neovascularization (CNV) owing to age-related macular degeneration (AMD) were evaluated with fluorescein angiography and OCT 3 months after PDT. The fluorescein angiograms were evaluated for staining of and leakage from the lesion and cystoid loculation of fluid in the macula. OCT examination was used to evaluate foveal thickness and the presence of subretinal fluid or cystoid loculation within the retina.
Results: The mean age of the 60 patients was 77 years and median visual acuity of the eyes examined was 20/100. The median number of previous PDT sessions was 2. Fluorescein staining was seen in 57 eyes (95%), and fluorescein leakage was seen in 50 eyes (83%). Cystoid loculation was seen in 21 eyes (35%). On OCT, cystoid spaces in the macula were seen in 42 patients (70%), and subretinal fluid was seen in 15 patients (25%). Leakage seen on FA correlated statistically significantly with cystoid spaces on OCT (p=0.0006, Fishers Exact Test), but not with subreti
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