Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Photodynamic Therapy for Circumscribed Choroidal Hemangioma – Clinical Findings and Functional Outcome

Jurklies B., Anastassiou G., Ortmans S., Schüler A., Schilling H., Bornfeld N.
Universitäts-Augenklinik, Essen

Purpose: To investigate the efficacy and to document the functional outcome of photodynamic therapy (PDT) with Verteporfin in patients with choroidal hemangioma.
Method: 22 patients with symptomatic choroidal hemangioma were included in a non-randomised, prospective clinical investigation. To be included the following criteria had to be present: a decrease in visual function (visual acuity), visual symptoms (e.g. metamorphopsia) and a subretinal exudation involving the fovea in response to the symptomatic choroidal hemangioma. 4 patients had been pre-treated unsuccessfully (external beam irradiation and laser photocoagulation) prior to enrolment to the study. They have been included to exclude any effects of preliminary interventions on the functional outcome. Photodynamic therapy (PDT) was performed with Verteporfin at a concentration of 6 mg/qm body surface area and a light dose of 100 J/qcm at 692 nm.
Results: The mean follow-up time was 26 months (2-40 months). The mean number of treatment sessions was 2 (range 1- 5). Visual acuity improved by at least one line in 77 %, by at least two lines in 45 %, was stable in 18 % and decreased by one line in 5 % of the patients. Exudation was completely resolved in 95% of the cases. Regression of tumour height was documented in all 22 tumours. Patients did not show any significant improvement in functional o

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