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Abstract
Abstract
Safety and Efficacy of Latanoprost in Pediatric Glaucoma
Autrata R., Řehurek J., Vančurova J.
Department of Ophthalmology, Masaryk University Hospital, Brno/CZ
Purpose: Latanoprost is a prostaglandin F2 analogue that substantially reduces intraocular pressure (IOP) via enhancement of uveoscleral outflow and IOP-lowering effect has been shown to be additive in combined therapy with other ocular hypotensive agents. The purpose of this study was to examine the effectiveness and safety profile of latanoprost therapy in children with glaucoma.
Method: This study was designed as a prospective study of all patients who were administered latanoprost at our clinic between January 1998 and December 2001. Sixty-four eyes of 51 pediatric patients with a variety of glaucoma diagnoses were included in the study, and were observed with an average of 21 months (range 13 to 37 months). The mean age of the patients was 7.8 years (range, 5 months to 16 years). The baseline IOP was compared with the IOP during the whole time of latanoprost therapy for each patient, visual acuity and side effects were noted at each follow-up examination. Responders were defined as those who had at least a 10% IOP reduction on latanoprost, whereas nonresponders showed less than a 10% IOP reduction on latanoprost.
Results: The mean pretreatment IOP was 24.9 ± 4.8 mm Hg, whereas the posttreatment IOP was 22.6 ± 7.5 mm Hg. The mean IOP reduction for this group after the addition of latanoprost was 9.2% (2.3 mm Hg). Twenty-one patients