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Abstract
Abstract
Lavasept® as Antiseptic Prophylaxis for Cataract-Surgery
Hansmann F.1, Kramer A.2, Ohgke H.3, Strobel H.4, Geerling G.1
1Department of Ophthalmology, 3Institute of Microbiology and Hygiene, 4Pharmacy, University Hospital Schleswig-Holstein, Campus Lübeck; 2Department of Hygiene, Greifswald
Purpose: Endophthalmitis is the most serious complication of intraocular procedures. 1.25% polyvinylpyrrolidon-(PVP)-Iodine is routinely used for intraoperative antiseptic prophylaxis. This can result in allergic reactions. A 0.04% solution of polyhexamethylbiguanid (PHMB) in combination with Polyethylenglycol may be an effective antiseptic alternative (Lavasept®, Fresenius-Kabi, Germany) that would avoid these iodine-associated side effects. In addition this substance is bound by mucous membranes in sufficient bactericidal concentrations for up to 3 days. The aim of this study is to examine the antiseptic potential and local tolerability of preoperative 0.04% PHMB (equal to 0.02% Lavasept®) for intraocular surgery. After presenting pilot-data in 2002 we here report the results of the randomised controlled trial.
Method: In a randomised, controlled double blind study 0.04% PHMB, 1,25% PVP-Iodine or Ringer-solution were applied in three groups of 20 patients three times preoperatively in addition to an intraoperative 1,25% PVP-iodine wash of the fornices. The degree of ocular surface symptoms like pain, conjunctival hyperaemia and epitheliopathy, and as well as t