Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Primary Intraocular Lymphoma with Unusual Presentation and Poor Outcome

Meyer P.1, Pache M.1, Flammer J.1, Dirnhofer S.2
1Dept. of Ophthalmology, 2Institute for Pathology, Basel University

Purpose: Primary intraocular lymphoma is a distinct subset of primary non-Hodgkin’s lymphoma of the CNS. Diagnosis can be difficult and is often delayed. Primary intraocular lymphoma can present as diffuse uveitis refractory to corticosteroids.
Results: We report the case of a 70-year old men with primary intraocular lymphoma. He presented with acute loss of vision due to vitreous hemorrhage. Diagnosis was established from vitrectomy material and later confirmed by histology of the enucleated eye. The lymphoma showed rapid local progression. In addition, a painful neovascular glaucoma with devastating visual loss developed, thus prompting us to perform an enucleation. The general physical examination (including CT/MRI of the brain) revealed no further manifestation of lymphoma. A high-dose therapy with methotrexat was initiated in due course.
Conclusions: Primary intraocular lymphoma often has a poor outcome. Early diagnosis is necessary in order to improve the prognosis. The clinical presentation can mimic a number of other ocular conditions such as diffuse uveitis or severe vitreous bleeding, as present in our case.


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