Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Three-dimensional Ultrasound Biomicroscopy and Scanning Electron Microscopy of the Human Zonula Ciliaris

Stachs O.1, Martin H.2, Behrend D.2., Schmidt K. P.2 und Guthoff R.1
1
Augenklinik, 2Institut für Biomedizinische Technik, Universität Rostock

Purpose: A biomechanical modeling of the accommodation process can be an essential tool for understanding the mechanism of accommodation and presbyopia against the background of accommodative lens replacing materials. The existing models are working with a very simplified zonula structure. The aim of this study was to investigate the benefit of three-dimensional ultrasonic imaging and scanning electron microscopy to elucidate the three-dimensional structure of the human zonule in view of an improved finite element model.
Method: Human eyes were scanned without invasive manipulation using a costum-made three-dimensional ultrasonic imaging technique with 50 micons spatial resolution and scanning electron microcopy (REM/ESEM).
Results: Fibres inserting on the anterior and posterior lens capsule emerge anteriorly at the ciliary body. No crossing fibres could be found. Fibres emerging near the ora serata insert on the lens and the posterior ciliary body. Typical course patterns was integrated in a finite element model of the accommodation.
Conclusions: Zonules description in natural environment without preparation artefacts allows physiological status studies and precise modeling of accommodation processes. These data form a basis for finite


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