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Abstract
Abstract
Elevated Cytokine Receptor Expression in Noninfective Uveitis
Callizo J.1, Metzner S.2, Otasevic L.2, Hartmann C.2, Pleyer U.2
1Universitat Autònoma de Barcelona; 2Dept. Ophthalmology, Charité-Campus Virchow Hospital, Humboldt University of Berlin
Purpose: Understanding of the role of cytokines in uveitis may provide new clues in the treatment. Therefore, the purpose of our study was to evaluate systemic cytokine receptor expression in patients with noninfective uveitis.
Method: Serum concentrations of soluble interleukin-2 receptor alpha (IL-2 s R alpha), soluble tumor necrosis factor alpha receptor-1 (sTNF-alpha R1) and monocyte chemoattractant protein-1 (MCP-1) were measured in patients with intermediate uveitis (n=26), posterior uveitis (n=23) and healthy controls (n=12) using ELISA (Quantikine, R&D Systems GmbH, Wiesbaden, Germany). All patients were identified in a consecutive series of 996 uveitis patients who had been diagnosed between 1998 and 2002 and classified according to the recommendations of the International Uveitis Study Group. Inclusion criteria were active intraocular inflammation, uveitis as a primary process and no systemic antiinflammatory treatment at the time of blood sampling.
Results: Serum concentrations of sIL-2 R alpha were significantly increased in patients with posterior (P< 0.05) and intermediate uveitis (P<0.01) as compared to healthy controls. Similarly, concentrations of TNF-alpha R1 appeared to be increased in posterior (P<0.05) and inte