Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
DOG Information
   DOG Information
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Ablauf der Tagung 2003
   General overview of congress
Lageplan der Räumlichkeiten
   Map of Congress Center
Wissenschaftliche Themen
   Scientific topics
Symposien
   Symposia
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Accompanying program
Arbeitssitzungen
   Working sessions
Rahmenprogramm
   Social program
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Industrieaussteller
   Commercial exhibitors
Sponsoren
   Sponsors
Impressum



DOG Homepage


Abstract
Abstract

Effectiveness of Pressure Lowering Treatment in Ocular Hypertension and Manifest Open-angle Glaucoma: A Meta-analysis of Randomized Controlled Trials

Maier P.1, Funk J.1, Schwarzer G. 2, Antes G. 2, Falck-Ytter Y.2
1Universistätsaugenklinik Freiburg; 2Deutsches Cochrane Zentrum, Universitätsklinik Freiburg, Institut für Med. Biometrie und Med. Informatik, Freiburg

Purpose: Ocular pressure-lowering treatments are widely used in glaucoma prevention, despite the fact that most people with ocular hypertension (OHT) alone, will not develop glaucoma. Interestingly, previous meta-analysis in OHT could not demonstrate a significant treatment effect. Additionally, treatment effectiveness in manifest glaucoma had not been shown in well-designed randomized controlled trials. We reassessed the effectiveness of pressure-lowering treatment in ocular hypertension and open-angle glaucoma.
Method: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and other databases were searched for relevant trials. Eligible studies were randomized controlled trials with a concurrent untreated control group and information about the onset of visual field deteriorations and definite glaucomatous disc changes.
Results: Meta-analysis of 4 adequate trials on treatment of ocular hypertension showed a significant preventive effect on progression to glaucoma (hazard ratio (HR): 0.55, 95% confidence interval (CI): 0.35 - 0.87, p=0.01). In manifest glaucoma with and without intraocular pressure elevation, only


Zurück | Back