Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

In vivo-representation of Corneal Histopathological Structures with the Rostock-confocal-laser-scanning-microscope after Epidemic Keratoconjunctivitis

Knappe S., Stave J., Guthoff R.
Department of ophthalmology University of Rostock

Purpose: The epidemic keratoconjunctivitis (EKC) is a highly contagious infection caused by adenovirus type 8, 19, 37. The genesis of subepithelial nummular infiltrates can lead to an permanent disturbance of vision. These infiltrates consist histopathologically of an accumulation of cells, like lymphocytes, histiocytes and fibroblasts. So far the cause of the persistence of the nummular infiltrates is not exactly known. The Rostocker-confocal-laser-scanning-mikroskop (KFM) allows us to recognize corneal structures in vivo and localize its depth exactly. The main interest of our work is to examine the cornea of a female patient during and after the acute phase of an epidemic keratoconjunctivitis with the KFM with special consideration of illness-specific changes.
Method: We examined a 28 years old female patient, who showed typical signs of an EKC infection. Besides a regular slit-lamp-microscopic investigations we accomplished a confocal cornea microscopy with the Rostocker-confocal-laser-scanning-microscope and compared both examination results together.
Results: After the acute infection, we saw particularly at the right eye multiple, central located, subepithelial nummuli in the cornea. The photographs with the confocal-laser-scanning-microscope showed a massive accumulation of dendritic cells as well as punctif


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