|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Retinal Edema Development - a Failure of Glial Cells
Bringmann A., Pannicke T., Iandiev I., Uckermann O., Biedermann B., Reichenbach A., Wiedemann P.
Macular edema, which contributes to photoreceptor degeneration and neuronal cell death, is an important complication in various diseases of the retina such as diabetic retinopathy and age-related macular degeneration. The relative importance of increased extracellular fluid versus swelling of Müller glial cells, which both can contribute to the development of macular edema, is uncertain. Swelling of Müller cells in the macula was described to frequently precede other signs of edema formation; and there are suggestions that the cysts in the cystoid macular edema are swollen Müller cells. However, while retinal ischemia was suggested to be one major factor which favor edema development, the pathogenesis of Müller cell swelling is unclear.