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Abstract
Abstract
Infrared Imaging of Classic Choroidal Neovascularisation Treated with Verteporfin Photodynamic Therapy
Weinberger A. W. A., Mazinani B. A. E., Musazadeh M., Schrage N. F.
University Eye Department, RWTH Aachen
Purpose: Imaging of retinal structures using scanning laser ophthalmoscopes can provide additional information compared to funduscopy or fundus photography. For example, autofluorescence imaging identifies lipofuscin deposition and pathologic changes within the retinal pigment epithelium, infrared imaging (IR) reveals drusen and pigmentary changes with high sensitivity. In cases of classic choroidal neovascularisation, photodynamic therapy (PDT) with visudyne has been established as a new treatment approach primarily in patients with age-related macular degeneration. In this study we analysed infrared images before and after treatment with visudyne and compared the images to fluorescein- and ICG-angiograms and clinical appearance.
Method: Patients with classic choroidal neovascularisation (CNV) which were eligible for photodynamic therapy with visudyne were recruited for the study. Infrared imaging at 795 nm as well as fluorescein and indocyanine green angiograms were gained with a HRA scanning laser ophthalmoscope (Heidelberg Engineering) in standard settings. Images were taken before PDT and 8 weeks after treatment, for up to 12 months.
Results: Twenty patients with classic choroidal neovascularisation could be included in the study, nineteen had age-related macular degeneration, one patient had retinopathia serpingiosa. Thirteen patients showed increa