Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Activation of L-type Ca2+ Channels by Fibroblast Growth Factors (FGF) in Cultivated Human Corneal Endothelial Cells: Differences between a-FGF and b-FGF

Mergler S.1, Dannowski H.2, Bednarz J.3, Engelmann K.3, Hartmann C.2, Pleyer U.2
University Hospital Charité, Campus Virchow, Humboldt University Berlin, 1Medical Clinic, Dept. of Gastroenterology, 2Dept. of Ophthalmology, 3Dept. of Ophthalmology, University Hospital  Eppendorf, Hamburg

Purpose: Growth factor families are important groups of proangiogenic factors in the cornea (FASEB J. 2002; 16: 1575-1583). For example, b‑FGF (basic-FGF) acts as an angiogenic factor triggering proliferation and migration as well as differentiation (Ger. J. Ophthalmol. 1996; 5: 346-351; Exp. Eye Res. 2000; 71: 583-589). Ca2+ channels play an important role in the intracellular response to FGF factors in different cell types (FASEB J. 2001; 15: 970-977). So far, Zurück | Back