Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

   Hotel Registration
   Welcome address
Beteiligte Gesellschaften
   Societies involved
DOG Information
   DOG Information
Eröffnung des Kongresses
   Opening Ceremony
Ablauf der Tagung 2003
   General overview of congress
Lageplan der Räumlichkeiten
   Map of Congress Center
Wissenschaftliche Themen
   Scientific topics
Wissenschaftliches Programm
   Scientific program
   Poster Presentation
Begleitende Veranstaltungen
   Accompanying program
   Working sessions
   Social program
Allgemeine Informationen
   General Information
   Index of Authors
   Commercial exhibitors

DOG Homepage


Effect of High Dose Systemic Acetazolamide on Ocular Hemodynamics and Retinal Vessel Diameters in Healthy Subjects

Schmidt K.-G., Müller M., Böhm A. G., Pillunat L. E.
Department of Ophthalmology, University of Dresden

Purpose: This study was designed to evaluate for the influence of the systemic carbonic anhydrase inhibitor acetazolamide on small retinal vessel diameters and ocular as well as systemic perfusion parameters on healthy volunteers.
Method: 8 healthy volunteers (26.6 ± 5.5 years; 6 males, 4 females) received acetazolamide (1000mg) orally. Baseline measurements were performed 15 minutes before drug application (T0) and parameters were determined as follows: Intraocular pressure (IOP, Goldmann), pulsatile ocular blood flow (POBF, OBF-System, OBF Labs U.K.), retinal capillary blood flow (RCBF, HRF-System, Heidelberg Engineering, Heidelberg, Germany), retinal arteriolar diameters (RAD, Retinal Vessel Analyzer, RVA; Imedos GmbH, Weimar, Germany) and systemic perfusion parameters (systolic and diastolic blood pressures, heart rate (HR)). The exact same measurements were performed at T15 (T0+15min), T30, T45, T60 and T75, respectively.
Results: IOP was altered as folllows: T0 (14.3 ± 2.9 mm Hg), T15 (- 2.8%, p > 0,1), T30 (- 21,9%, p = 0,053), T45 (- 22,6%, p = 0,04), T60 (- 30%, p = 0.01) and T75 (- 25.9%, p = 0.03). All other parameters investigated were not (sig.) altered during the course of this experiment. Maximum change in RCBF (+ 45.4 %, p = 0.081), RAD (+ 3.6 %, p = 0.075) and HR (- 3.6 %, p = 0.054) was at T45.
Conclusions: Result

Zurück | Back