Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Oxygen Saturation in Retinal Vessels after Provocation with Pure Oxygen by Diabetics with Moderate Non-proliferative Retinopathy and Healthy Probands

Voigt U.1, v. d. Vorst S.1, Lasch A.1, Hammer M.1, Schweitzer D.1, Müller U. A.2, Strobel J.1
1Augenklinik, 2Klinik für Innere Medizin II, Friedrich-Schiller-Universität, Jena

Purpose: Vasoconstriction and increased oxygen saturation in retinal vessels are observed during a respiration of pure oxygen. The reaction of oxygen saturation in retinal vessels during oxygen provocation will studied in a comparison between diabetics (with moderate non proliferative retinopathy) and healthy probands.
Method: Using the Jena Imaging Spectrometer, the oxygen saturation was measured in retinal arteriols and venols before, during (6 min. after start) and 15 minutes after stop of oxygen respiration in 13 diabetics with moderate retinopathy and 13 healthy probands. Additionally, blood pressure, concentration of blood glucose and HbA1c were registrated.
Results: In arteriols the oxygen saturation increased in both groups during oxygen respiration significantly (p<0,05). The saturation increased from 87± 9% to 95± 7% in the healthy group and from 86± 14% to 96± 8% in the diabetic group. After interruption of oxygen respiration the oxygen saturation decreased to 89± 10 in the control group and to 89± 10 in diabetics. Only in the normals this difference was significant (p<0,05).In venols, oxygen saturation increased d


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