Optical Coherence Tomography (OCT) in Age-related Macular Degeneration (AMD) - How Does OCT Help Us?
Hassenstein A., Rühl R., Richard G.
Universitäts-Augenklinik mit Poliklinik Hamburg-Eppendorf
Purpose: OCT was used to evaluate the diagnostic value for treatment indications in AMD besides other established methods such as fluorescein angiography (FLA).
Method: 147 patients (187 eyes) suffering from different stages of AMD were examined by FLA and OCT. 45 patients had soft drusen (52 eyes), 37 suffered from geographic atrophy (55 eyes), 65 patients had choroidal neovascularization (CNV) (80 eyes) predominantly classic (36; 42 eyes) or predominantly occult (29; 38 eyes). Results of examinations from FLA and OCT were compared.
Results: Hard drusen were not detectable in OCT. Soft drusen were visible in OCT as focal serous detachments of the retinal pigment epithelium (RPE). Geographic atrophy revealed in OCT a significant thinning of the fovea of 135mm compared to healthy volunteers of 158mm (p<0,0005). OCT showed an increased choroidal reflectivity as sharply demarcated vertical reflective band due to lacking RPE. In 3 of 55 patients (5%) OCT only detected a macular hole. CNV showed in OCT not only a spindlelike thickening of the RPE/choriocapillaris-layer but as well a cystoid formation or detachment of the retina: 100% classic CNV cystoid formation 6%, neurosensory detachment 58%, >50% classic CNV cystoid formation 25%, neurosensory detachment 42%; >50% occult CNV cystoid formation 66% and neurosensory de
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