Hotelbuchung
Hotel Registration
Grußwort
Welcome address
Beteiligte Gesellschaften
Societies involved
DOG Information
DOG Information
Eröffnung des Kongresses
Opening Ceremony
Preise
Awards
Ablauf der Tagung 2003
General overview of congress
Lageplan der Räumlichkeiten
Map of Congress Center
Wissenschaftliche Themen
Scientific topics
Symposien
Symposia
Wissenschaftliches Programm
Scientific program
Posterpräsentationen
Poster Presentation
Kurse
Courses
Begleitende Veranstaltungen
Accompanying program
Arbeitssitzungen
Working sessions
Rahmenprogramm
Social program
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Industrieaussteller
Commercial exhibitors
Sponsoren
Sponsors
Impressum
DOG Homepage
Abstract
Abstract
Adjuvant Decorin Therapy for Wound Healing Suppression after Filtrating Glaucoma Surgery
Grisanti S., Szurman P., Ziemssen F., Warga M., Denk P. O., von Eicken J., Bartz-Schmidt K. U.
Center of Ophthalmology, Department I, Eberhard-Karls University Tübingen
Purpose: To evaluate the antifibrotic effect of subconjunctival injection of Decorin after glaucoma filtering surgery in a rabbit model.
Method: Rabbits (ChBB:CH; n=15) received filtering surgery on the right eye and were divided into three groups (n=5): group 1 without adjuvant therapy, group 2 with 0.04 mg Decorin and group 3 with 0.1 mg Decorin. Rabbits in the groups 2 and 3 received subconjunctival injection of Decorin 15 min before surgery and in the four successive postoperative days. Operative procedure comprised: preparation of a 2.5 x 2.5 mm scleral flap, trepanation with a 1.5 mm trephine and subsequent iridectomy. Antifibrotic efficacy was established by clinical response and histological examination. A successful reduction of the intraocular pressure (IOP) was defined as IOP-ratio (between the treated experimental right eye and the left eye) < 0.8. After 2 weeks, the eyes were enucleated and processed for histological examination.
Results: In group 1 intraocular pressure exceeded a ratio of 0.8 at 7 days postoperatively, while groups 2 and 3 maintained a pressure ratio less than 0.8 during the follow up time of 2 weeks. After 14 days eyes with group 2 disclosed a mean ratio of 0.75±~.09 and group 3 a ratio of 0.58±0.11. Histology in control eyes disclosed a mar