|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
In vitro Cornea Model A New Opportunity in Organ Culture and a Test System Replacing in vivo Experiments
Nietgen A. M.1, Keller-Kuckelkorn G. K.1, Salla S.1, Kondring B.1, Frentz W.2, Reim M.1, Schrage N. F.1
Purpose: Corneal perfusion chambers are important tools in the development and assessment of ophthalmic drugs. On the other side we will present another opportunity for long time cornea perfusion. The aim of our study was to design and test a modified perfusion chamber suitable for topical drug application to the isolated rabbit cornea and additionally continuous monitoring of endothelial and epithelial cell function.