Hotelbuchung
Hotel Registration
Grußwort
Welcome address
Beteiligte Gesellschaften
Societies involved
DOG Information
DOG Information
Eröffnung des Kongresses
Opening Ceremony
Preise
Awards
Ablauf der Tagung 2003
General overview of congress
Lageplan der Räumlichkeiten
Map of Congress Center
Wissenschaftliche Themen
Scientific topics
Symposien
Symposia
Wissenschaftliches Programm
Scientific program
Posterpräsentationen
Poster Presentation
Kurse
Courses
Begleitende Veranstaltungen
Accompanying program
Arbeitssitzungen
Working sessions
Rahmenprogramm
Social program
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Industrieaussteller
Commercial exhibitors
Sponsoren
Sponsors
Impressum
DOG Homepage
Abstract
Abstract
Progression of Atrophy and Visual Loss in Geographic Atrophy due to Age-related Macular Degeneration (AMD)
Bindewald A.1, Sieber H.1, Schmitz-Valckenberg S.1, Jorzik J. J.1, Miller D. W.1, Schuldt A.2, Keilhauer C.3, Weinberger A.4, Wolf S.5, Mansmann U.2, Holz F. G.1 for the FAM-Study Group
Dept. of Ophthalmology1 and Institute for Medical Biometry2, University of Heidelberg, Depts. of Ophthalmology University of Würzburg3, RWTH Aachen4, University of Leipzig5
Purpose: Geographic atrophy (GA) is a common cause for severe visual loss in advanced AMD. We determined the natural history of patients with GA based on delineation of atrophic patches and their variation over time in fundus autofluorescence (AF) images.
Method: 86 eyes of 57 patients with uni- or bilateral GA were followed on average over 2.9 years (interquartil distance IQD 1.3-4.3) in a prospective longitudinal study in an arm of the multicenter FAM-Study. Fundus AF images were obtained with a confocal scanning laser ophthalmoscope (cSLO, exc. 488 nm, em >500 nm, Heidelberg Retina Angiograph, Heidelberg Engineering). GA areas were identified based on their markedly decreased AF-signal and quantified with an automated image analysis method (Global Lab Image/2) or by manual outlining. Bestcorrected visual acuity was dermined usind ETDRS-charts.
Results: Atrophy enlarged by 1.44 mm2 per year (IQD 0.6-1.8) in an alm