|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
p53 Expression in Conjunctival Neoplasias. Investigations of Bioptic Material from Africa
Timm A.1, Stropahl G.2, Sinzidi C.3, Fischer K.4, Schittkowski M.1, Reisinger E.5, Guthoff R.1
Purpose: In African sub-Saharan countries, an increasing incidence of epithelial tumors of the conjunctiva was observed in connection with rising HIV infection rate. The definite cause of these tumors is not well-known. Ultraviolet radiation are considered as a main factor of risk. Mutations of the tumor suppressor gene p53 probably represent frequent and initial changes in the emergence of radiation-induced epithelial skin tumors and could appear in analogy also at the conjunctiva. At specimens from the conjunctiva possible indications of an UV radiation induced tumorgenesis should be analysed.