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Abstract
Abstract
p53 Expression in Conjunctival Neoplasias. Investigations of Bioptic Material from Africa
Timm A.1, Stropahl G.2, Sinzidi C.3, Fischer K.4, Schittkowski M.1, Reisinger E.5, Guthoff R.1
1Clinic of Ophthalmology, 2Institute of Pathology and 5Clinic of Internal Medicine, University of Rostock, Germany; 3Clinic of Ophthalmology, University of KinshasaZRE
4Christoffel Blind Mission, Masvingo, Simbabwe and Bafoussam, Kamerun
Purpose: In African sub-Saharan countries, an increasing incidence of epithelial tumors of the conjunctiva was observed in connection with rising HIV infection rate. The definite cause of these tumors is not well-known. Ultraviolet radiation are considered as a main factor of risk. Mutations of the tumor suppressor gene p53 probably represent frequent and initial changes in the emergence of radiation-induced epithelial skin tumors and could appear in analogy also at the conjunctiva. At specimens from the conjunctiva possible indications of an UV radiation induced tumorgenesis should be analysed.
Method: Specimens of 82 patients (53 female, 29 male; average age 40.1 years) from three African centres with the following histological lesions were examined: papillomas (2), pingueculae (6), conjunctival intraepithelial neoplasias (9 CIN I, 14 CIN II, 24 CIN III) and squamous cell carcinomas (SCC, 27 cases). Immunohistological reaction for p53 was done in all samples. 32 of 48 tested patients were HIV positive.
Results: