|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Antimicrobial Peptides in Human Lacrimal Gland, Cornea and Conjunctiva Beta-defensin 2 and Psoriasin are Induced in Dry Eye
Paulsen F.1, Thale A. 2, Jansen A.1 , Geerling G3, Schaudig U4, Al-Samir K.4, Mentlein R.1, Varoga D.1
Purpose: Antimicrobial peptides (AMP) are thought to be effectors of innate immunity through their antibiotic activity and direct killing of microorganism. The induction of AMPs is mediated by activation of human Toll-like-receptors (TLRs) through pathogen-associated microbial products or cytokines. In the present study, we wanted to determine the induction, expression and production of AMP by acinus cells of the lacrimal gland as well as by conjunctival and corneal cells in healthy and pathologic states.