Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Plasma Homocysteine is Elevated in Patients with Open-angle Glaucoma

Jünemann A.1, von Ahsen N.3, Kornhuber J.2, Ritter K.2, Naumann G. O. H.1, Bleich S.2
1Department of Ophthalmology, 2Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, 3Department of Clinical Chemistry, Georg-August-University of Göttingen, Germany

Purpose: Homocysteine can induce alterations in extracellular matrix and neuronal cell death that are characteristic findings in glaucoma. Moderate hyperhomocysteinaemia has been related to genetic or non-genetic risk factors that alter enzyme activity in the transsulfuration or remethylation pathways. This study was therefore undertaken to investigate whether homocysteine levels are altered in patients suffering from primary open-angle glaucoma (POAG) or secondary open-angle glaucoma due to pseudoexfoliation (PEXG).
Method: Total plasma homocysteine (Hcy) and vitamins relevant in its metabolism (folate, B12, B6) were determined in patients with POAG (n=18), SOAG (n=19), and 19 controls with cataracts. Patients with other risk factors for hyperhomocysteinemia were excluded. Making the groups maximally comparable controls were matched to cases by age, gender and concurrent diagnosis of systemic hypertension. All patients were well feeded, thus Hcy levels >11.7mmol/l are abnormal.
Results: Significantly raised plasma Hcy levels were found in POAG (12.52mmol/


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