Hotelbuchung
Hotel Registration
Grußwort
Welcome address
Beteiligte Gesellschaften
Societies involved
DOG Information
DOG Information
Eröffnung des Kongresses
Opening Ceremony
Preise
Awards
Ablauf der Tagung 2003
General overview of congress
Lageplan der Räumlichkeiten
Map of Congress Center
Wissenschaftliche Themen
Scientific topics
Symposien
Symposia
Wissenschaftliches Programm
Scientific program
Posterpräsentationen
Poster Presentation
Kurse
Courses
Begleitende Veranstaltungen
Accompanying program
Arbeitssitzungen
Working sessions
Rahmenprogramm
Social program
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Industrieaussteller
Commercial exhibitors
Sponsoren
Sponsors
Impressum
DOG Homepage
Abstract
Abstract
Simultaneous Amniotic Membrane Transplantation in High-risk Keratoplasty
Seitz B., Sauer R., Hofmann-Rumelt C., Wenkel H., Langenbucher A., Naumann G. O. H.
Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany
Purpose: With limbal stem cell insufficiency (e.g. aniridia) or chronic polyarthritis (cP) epithelial healing problems after penetrating keratoplasty (PK) (especially à chaud) are common. The amniotic membrane (AM) is supposed to promote re-epithelialization, and to have antiinflammatory and antiangiogenic properties. In an experimental study it was further shown, that the AM itself is an immunprivileged tissue and may transfer this property to co-transplanted corneas, thus considerably decreasing their alloimmunogenity. The purpose of this study was to investigate the short- and intermediate-term results of simultaneous AM transplantation (AMT) in high-risk keratoplasties.
Method: From 01/2001 to 02/2003 a simultaneous AM-Patch (diameter 14 to 16 mm) was sutured episclerally in 16 patients (9 males, age 38 to 92 (73±14) years) directly following PK (diameter 3.5 mm eccentric to 8.0 mm central). In 13 eyes a soft contact lens was applied intraoperatively. Diagnoses included: 5x cP or Sjögren's syndrome, 4x bacterial ulcer with hypopyon, 2x ulcerative herpetic keratouveitis, 2x limbal stem cell insufficiency (aniridia or trauma), 1x ocular pemphigoid, 1x candida endophthalmitis and 1x acute stromal graft rejection with melting. Out of 14 eyes with emergency keratoplasties (à chaud), 10 corneas were perforated. Five patients received systemic