Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

The Pathology of the Corneal Endothelium

Wilhelm F.
Dept. of Ophthalmology, Halle University

Purpose: The cornea endothelium is the most vulnerable layer of this tissue. Its regularly function is responsive to the excellent clearness of the cornea. The lost of function can caused by different diseases of the endothelium. Because there are normally no mitosis in the endothelial cells keratoplasty is the most performed transplantation of human tissue. Only grafts with enough functioning endothelium and exact examination in an certificated eye bank should be transplanted.
Method: An Overview about the different diseases of the cornea endothelium shows, that additionally to the Fuchs dystrophy the mostly indication of cornea transplantation is the postoperative state after cataract surgery and trauma.
Results: Different methods for estimation the endothelium - in living individuals like specular and konfocal microscopy, in separated eye bank corneas like phase contrast method and vital staining and for using in experimental studies like scanning electron microscopy are demonstrated with typical findings.
Conclusions: The exact diagnosis of cornea endothelial diseases is necessary to can tell the patients anything about the prognosis and the possibilities of treatment. The lack of donor corneas all over the world makes it necessary to find new ways in endothelial transplantation.


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