Hotelbuchung
Hotel Registration
Grußwort
Welcome address
Beteiligte Gesellschaften
Societies involved
DOG Information
DOG Information
Eröffnung des Kongresses
Opening Ceremony
Preise
Awards
Ablauf der Tagung 2003
General overview of congress
Lageplan der Räumlichkeiten
Map of Congress Center
Wissenschaftliche Themen
Scientific topics
Symposien
Symposia
Wissenschaftliches Programm
Scientific program
Posterpräsentationen
Poster Presentation
Kurse
Courses
Begleitende Veranstaltungen
Accompanying program
Arbeitssitzungen
Working sessions
Rahmenprogramm
Social program
Allgemeine Informationen
General Information
Autorenindex
Index of Authors
Industrieaussteller
Commercial exhibitors
Sponsoren
Sponsors
Impressum
DOG Homepage
Abstract
Abstract
SupraDescemetic Synthetic Cornea (sDSC) Preliminary Results of a Novel Non-penetrating Keratoprosthesis in the Rabbit Model
Stoiber J.1,2, Fernandez V.1, Kaminski S.3, Lamar P. D.1, Lacombe E.4, Duchesne B.5, Parel J.-M.1,5,6
1Bascom Palmer Eye Institute, Ophthalmic Biophysics Center Univ. of Miami, USA; 2Landesklinik für Augenheilkunde und Optometrie, Private Medizinische Universität Salzburg, Austria; 3Universitätsklinik für Augenheilkunde und Optometrie, University of Vienna (AKH), Austria; 4Rothschild Foundation, Paris, France; 5CHU Sart-Tilman, University of Liege, Belgium; 6University of Paris XI Hotel-Dieu Hospital, France
Purpose: To show feasibility and biocompatibility of a novel non-penetrating keratoprosthesis (supraDescemetic Synthetic Cornea, sDSC) in a rabbit model.
Method: A new surgical technique was developed to implant the keratoprothesis (7 mm diameter, 450mm thick optical zone) on top of a bare Descemets membrane (DM). 4 different materials were tested in this series: hydrophobic PMMA, hydrophilic pHEMA-MMA26, pHEMA-MMA34 and pHEMA-NVP75. The device was successfully implanted in healthy eyes of 17 New Zealand White rabbits and followed for up to 7 months to date. 7 rabbits were selected for histological evaluation. In 16 rabbits an ocular surface injury was created by application of 1-heptanol onto the cornea and surgical removal of the limbus, leading to vascularisation and scarring.