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Abstract
Abstract
Adiponectin A New Candidate Antigen in Graves Ophthalmopathy (GO)?
Plicht M.1, Morgenthaler N.3, Steuhl K. P.1, Quadbeck B.2, Mann K.2, Esser J.1, Eckstein A.1
1Department of Ophthalmology, University Essen, 2Department of Medicine, Division of Endocrinology, University Essen, 3BRAHMS AG, Research, Biotechnology Centre Hennigsdorf/Berlin, Germany
Purpose: Adiponectin is a novel adipose tissue-specific protein. Synthesis and secretion of adiponectin is increased by the activation of the nuclear receptor PPARgamma. Recently a male type-2 diabetic, treated with the PPARgamma agonist Pioglitazone, experienced exacerbation of his GO. So we framed the hypothesis, that marked and lid swelling and proptosis, which are mainly caused by increased orbital adipose tissue, might be accompanied by increased adiponectin levels in GO.
Method: Adiponectin serum levels were evaluated in 166 GO patients in different activity (CASscore) and severity (NOSPECSscore) stages and in 25 normal controls. Patients had either activ GO = CAS > 2 or inactiv GO CAS Zurück | Back