Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Influence of Inflammation on Development of Secondary Degeneration in Lattice Dystrophy (Type 1)

Drozhyna G. I., Vit V. V., Dumbrova N. E., Marichev Y.
The Filatov Institute of Eye Disease, Odessa, Ukraine

Purpose: In spite of average, age keratoplasty by lattice dystrophy (LD) is 40 - 50 years, the age of the first keratoplasty varies between 20 and 70 years. Except dystrophy, there are other factors which influence the development of pathological changes in the cornea. The most frequent symptom of the LD is the recurrence erosion (RE), which can be complicated by different inflammatory processes. The aim was to study changes in clinical picture and morphological findings by inflammatory processes of cornea in LD.
Method: Clinical studies were performed in 66 patients (132 eyes) in age 15 - 69 years (M = 43.7±SD11.4). The type and frequency of the inflammatory process in the cornea, degree of degeneration, of lacrymalsecretion were evaluated. Morphological studies were conducted in 28 corneal buttons after lamellar keratoplasty, among them electron microscopic studies were performed in 9 corneal buttons.
Results: Presence of (RE) in anamnesis was established in 128 eyes (97.1%). 39 eyes of 37 patients (56.1%) were treated in clinic with different inflammatory processes: persistent defects of epithelium 6 eyes(15.4%), keratitis 23 (56.1%)


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