|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Endothelin and Glaucoma
Thiéme H., Foerster M. H.
Lowering intraocular pressure either pharmacologically or surgically is still the main mode of intervention in treating glaucoma effectively. Additionally ocular blood flow in the retina or choroid as well as the optic nerve appears to be impaired in the disease. Endothelin is a potent vasoconstrictor and its concentrations were found to be increased in the aqueous humor of POAG patients as well as the plasma of normal tension gaucoma patients. Blocking Endothelin in healthy subjects increases ocular blood flow. Whether or not Endothelin plays a pivotal role in the pathogenesis of Glaucoma remains an open question and is currently under investigation. Certain types of antiglaucomatous substances appear to lower introcular pressure through an anti-endothelin action. This presentation will highlight our current understanding about Endothelin and Glaucoma in respect to clinical and animal studies as well as pharmacological information.