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Association of Malignant Tumors of the Conjunctiva and HIV-infection in Kinshasa (D.R.Kongo)

1Timm A., 1Schittkowski M., 2Stropahl G., 1Krüger H., 3Sinzidi C., 3Kayembe D. L., 1Guthoff R.,
1Universität Rostock, Augenklinik (Rostock)
2Universität Rostock, Institut für Pathologie (Rostock)
3Service d`Òphthalmologie, Cliniques Universitaires de Kinshasa (Kinshasa)

Purpose: Carcinomas of the conjunctiva are tumors of the 6./7 decade. They occur in Germany with a frequency of 1/20 000. It has been well known for years that in Africa the amount of malignant tumors of the conjunctiva is increasing. It is the aim of this study to examine the association of carcinomas of the conjunctiva with an HIV infection in the region of Central Africa in Kinshasa (D.R. Congo).
Method: A histological examination of 35 patients took place in Rostock, when a conjunctival tumor was removed at the University eye hospital of Kinshasa in 2001. It concerned 12 male and 23 female patients at the age of 20 to 75 (means 41) years. In all patients a serological investigation was executed on an HIV-infection in Kinshasa.
Results: 18 of 35 patients were HIV positive. From the HIV positive patients 6 patients (33%) showed a squamousa cell carcinoma. 7 patients (39%) showed a dysplasia and with 5 patients (28%) concerned it a pinguecula. From the HIV negative patients 5 patients (29%) showed a squamousa cell carcinoma. 8 patients (47%) showed a dysplasia, 1 patient a pinguecula, 1 patient a carcinoma from gland, 1 patient a papilloma and for one patient it was not possible to carry out a histological evaluation. The average age of the HIV positive patients with a squamousa cell carcinoma amounted to 41 years and that of the HIV negative patients 58 years.
Conclusions: A squamousa cell carcinoma was slightly more frequent in HIV infected patients. Whereby the HIV positive patients were on the average 17 years younger. The increasing number of younger patients suggest in addition to the UV-radiation, further Co- factors of carcinogenesis in particular a HIV infection. Investigations on additional virale infections as possible pathogenetic factors are planned.