Changes in Fundus Autofluorescence in Patients with Age-Related Maculopathy in Correlation to Visual Function: A Prospective Study
Einbock W.1; Mößner A.1, Schnurrbusch U.E. K.1; Holz F. G. 2; Wolf S.1
FAM-Study Group, 1Dept. of Ophthalmology, University of Leipzig, 2Dept. of Ophthalmology, University of Heidelberg
Purpose: The fundus autofluorescence in age-related macular degeneration study group (FAM-Study group) aims to identify autofluorescence (AF) changes as predictive factors for the progression of AMD. We report changes of fundus AF in patients with multiple soft drusen in correlation to visual function.
Method: Patient with age-related maculopathy were recruited from the outpatient department. Inclusion criteria were age > 50 years, the presence of large soft drusen, visual acuity of 20/100 or better, and no previous laser treatment in the study eye. All patients underwent a detailed ophthalmological examination including ETDRS visual acuity, binocular funduscopy, and color fundus photography. All examinations were repeated every 6 month. AF imaging was performed with a confocal scanning laser ophthalmoscope (HRA, Heidelberg Engineering, Germany) following a standard protocol. AF images were analyzed for focal areas of increased or decreased fundus autofluorescence. Additionally, changes in fundus autofluorescence were correlated to visual acuity.
Results: One hundred twenty patients (75 woman, 55 men) aged from 55-86 years (mean 72
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