|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
VEGF in exudative ARMD
Vascular endothelial growth factor (VEGF) is a specific proliferation factor for vascular endothelial cells and the most potent permeability factor. Age related macular degeneration (ARMD) is characterized by choroidal neovascularisations (CNV) and by impairment of the outer blood retinal barrier. Expression of VEGF could be demonstrated in surgically removed CNV. In vitro RPE have been shown to synthesize VEGF. When RPE cells were cocultivated with vascular endothelial cells they developed lower barrier properties. This effect was dependent on VEGF.