|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Carbonylgroups Introduced in Proteins by Oxidative Modifications in Normal Macula and CNV-Lesions by Exudative AMD
Hermans P.1,3, Lommatzsch A.2, Wasmuth S.3, Bauer D.1 , Müller D.4, Bornfeld N.3, Pauleikhoff D.2
Purpose: Oxidative stress can modify proteins that frequently result in functional changes, such as impaired enzymatic activity, decreased/increased DNA binding activities of transcription factors, and decreased susceptibility to proteolytic degradation. The aim of the present study was to detect carbonyl groups introduced in protein side chains by reactive oxygen species (ROS) or by reaction with aldehydes (malondialdehyd) in normal macula and choroidal neovascularisation membranes (CNV) from patients with exudative age-related macular degeneration (AMD).