|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Pathogenesis of Vitreoretinal Membranes in Mice with Targeted Disruption of the Norrie Gene
Fuchs A. V.1, Adamek E.2, Ohlmann A.2, Kampik A.1, Lütjen-Drecoll E.2
Purpose: In patients with Norrie disease (ND) and in gene targeted ND mutant mice retinal degeneration associated with impaired capillarisation as well as membranous lesions of unknown origin within the vitreous have been described. Previous studies suggested persisting hyaloid vessels (HV) as major component of these membranes. Endostatin, an angiogenetic inhibitor is known to play a role for the regression of HV during ocular development. The purpose of this study was to further characterise these membranes in ND mice and to assess the role of endostatin for their formation.