|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Hypoxia Increases the Expression of CTGF and PAI-1 in Retinal Pigment Epithelium
Welge-Lüßen U.1, R. Fuchshofer R.2, Kampik A.1, Lütjen-Drecoll E.2
Purpose: Early age related macular degeneration (ARMD) is characterised by atrophia of the choroid and the thickening of Bruch´s membrane by the accumulation of extracellular matrix (ECM). These findings could be related to hypoxia of the outer retina and retinal pigment epithelium (RPE). One factor known to increase the formation of ECM is connective tissue growth factor (CTGF). Additional CTGF has been proposed to be involved in the angiogenesis. The enzyme plasminogen activator inhibitor-1 (PAI-1) inhibits the degradation of ECM. In the present study we have investigated the effect of hypoxia on the expression of CTGF and PAI-1 in cultivated human RPE cells.